Neuropharmacology: Oxime antidotes for organophosphate pesticide and nerve agent poisoning
نویسندگان
چکیده
منابع مشابه
Antidotes for tetramine poisoning.
In medicine, the following definition based on Hobb’s recommendations is commonly used: (a) Abuse is a willful and deliberate act by a caregiver resulting in physical injury of the child. (b) Neglect is the failure of the caregiver to take minimal precautions for the proper supervision of the child’s health, thus failing to protect the child from injury. (c) Accident is a lapse in the usual pro...
متن کاملPoisoning - antidotes and their use
J A N UA RY 2 0 0 7 • VO L . 1 4 1 0 • H O S P I TA L P H A R M AC I S T Antidotes play a crucial part in the management of certain poisons, but they are only available for a small number of drugs and chemicals. As pointed out in the previous article (p7), antidotes are only one aspect of the management of a poisoned patient. Until recently, there were no nationally recognised guidelines for em...
متن کاملPralidoxime for organophosphate poisoning
From their randomised trial, Kirti Pawar and colleagues report in today’s Lancet on two pralidoxime-dosing schemes in 200 patients who had moderately severe self-poisoning with organophosphorus insecticide. After a 2-g loading dose over 30 min, half received a high-dose regimen of 1 g/h pralidoxime iodide for 48 h. The other half received a lower dose: 1 g/h every 4 h. After 48 h, the lower dos...
متن کاملFrom the Research of Cholinesterase Reactivators to the Effective Therapy of Organophosphate/nerve Agent Poisoning
Nerve agents belong to the most toxic organophosphates (OP) in the group of cholinesterase inhibitors. They can be used as chemical warfare agents and, they can be (and were) misused by terrorists, as happened in Matsumoto city (1994) and Tokyo subway (1995). Sarin was used in these cases. Medical protection against their effect (i.e. antidotal treatment) is of prime importance (Bajgar 2004, 20...
متن کاملOrganophosphate Poisoning
They are used as pesticides but can also be used as 'nerve gas'. This is prohibited under the Geneva Convention but could be used by terrorists or rogue regimes. There is some suggestion that the use of OP pesticides may have caused some neurotoxicity and be responsible for 'Gulf War syndrome'. Certainly, insecticides were freely used, as were many other chemicals. The syndrome is inconsistent ...
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ژورنال
عنوان ژورنال: Periodicum Biologorum
سال: 2020
ISSN: 0031-5362
DOI: 10.18054/pb.v121-122i1-2.10623